10 months agoPSG to make opening offer for Arsenal midfielder Aaron Ramsey

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say PSG to make opening offer for Arsenal midfielder Aaron Ramseyby Paul Vegas10 months agoSend to a friendShare the lovePSG are making an opening offer for Arsenal midfielder Aaron Ramsey.The Mirror says PSG are keen on a £9million January move for Ramsey.The Arsenal midfielder is out of contract at the end of the season after the north Londoners withdrew their offer of a new contract this season.The French champions are ready to move for him when the transfer window reopens to head off interest from Juventus and Bayern Munich.PSG want to strengthen their midfield options with Adrien Rabiot expected to move to leave the club either in January or next summer. last_img

10 months agoEmery approves Arsenal move for Dalian Yifang winger Carrasco

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Emery approves Arsenal move for Dalian Yifang winger Carrascoby Paul Vegas10 months agoSend to a friendShare the loveArsenal boss Unai Emery has approved a move for Dalian Yifang winger Yannick Carrasco.The Belgian winger, formally of Atletico Madrid, has been heavily linked with the Gunners over the past few weeks.The 25-year-old has been playing in the Chinese Super League since 2015, but could now be set for a sensational return to Europe.Foot Mercato says Emery is a big fan of the winger and has given his permission for Arsenal to launch a bid for the Belgium ace.However, Arsenal will have their work cut out as Dalian Yifang are unwilling to part with the man who has scored seven goals in 26 appearances this season. last_img read more

25 days agoLiverpool manager Klopp to add to backroom staff

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Liverpool manager Klopp to add to backroom staffby Paul Vegas25 days agoSend to a friendShare the loveLiverpool manager Jurgen Klopp is set to add another member to his backroom staff.According to the London Evening Standard, Porto coach Vitor Matos is close to joining the Anfield club.The Portuguese will take on the responsibility of closing the gap between the academy and the first-team.It was the role previously held by Pep Lijnders before he was promoted following the departure of Zeljko Buvac.Matos previously worked alongside Lijnders at Porto.The 31-year-old enjoyed a two-year stint in China sandwiched in between spells at the Primeira Liga club. last_img

8 days agoMan Utd teenager Williams signs new contract

first_imgAbout the authorFreddie TaylorShare the loveHave your say Man Utd teenager Williams signs new contractby Freddie Taylor8 days agoSend to a friendShare the loveManchester United have tied down Brandon Williams to a new contract.The promising teenager was impressive on debut in the Europa League draw with AZ Alkmaar last month.The new deal will keep him at United until June 2022, with the option to extend for a further year.Speaking after the AZ result, manager Ole Gunnar Solskjaer was full of praise for the young fullback.”You won’t see a better full debut from a full back anywhere,” the Red Devils coach said.”The boy is just going to improve and improve. He’s got the right mentality. I’m very pleased for him.” last_img

2 days agoArsenal legend Wright has Nketiah advice for Bielsa

first_imgAbout the authorPaul VegasShare the loveHave your say Arsenal legend Wright has Nketiah advice for Bielsaby Paul Vegas2 days agoSend to a friendShare the loveArsenal legend Ian Wright has lead the chorus of supporters asking for Eddie Nketiah to start Leeds’ next match.The 20-year-old scored his third goal of the season to rescue a point for the Whites in Tuesday’s 1-1 draw with Preston.It was Nketiah’s 11th substitute appearance, having not been started once by Marcelo Bielsa.And Gunners legend Ian Wright, who has given Nketiah advice this season, has demanded Bielsa change his starting line-up.Wright wrote simply on Twitter: “Start him.”Both Leeds and Arsenal supporters echoed the statement across social media. last_img

Qatargas Delivers Inaugural Cargo to Yuedong LNG Terminal

first_imgImage Courtesy: QatargasQatar-based liquefied natural gas (LNG) company Qatargas recently delivered the inaugural cargo of LNG to China National Oil Corporation’s (CNOOC) Yuedong LNG terminal.The cargo, delivered on board the Qatargas-chartered Q-Flex LNG vessel Al Kharaitiyat, was used to commission CNOOC’s newest LNG terminal.“Qatargas is delighted to supply the commissioning cargo to CNOOC’s Yuedong Terminal. We are also pleased to see Qatari LNG playing an increasingly important role in meeting the growing demand for LNG in the People’s Republic of China,” Khalid Bin Khalifa Al-Thani, Chief Executive Officer of Qatargas, said.The Yuedong LNG receiving terminal, which has an initial receiving capacity of 2 MTPA, is owned and operated by CNOOC. The new terminal joins the company’s existing terminals in Shanghai, Guangdong, Fujian, Zhejiang and Hainan.This is the fourth commissioning cargo from Qatargas to CNOOC’s LNG terminals, bringing Qatargas’ total number of inaugural cargoes to LNG terminals in China to seven.last_img read more

A Website Went Offline And Took Most Of Womens College Basketball Analytics

If you’re filling out your bracket for the NCAA men’s basketball tournament and want some statistical background to the broader forecasts, you have a slew of options. Start at Sports-Reference.com: powerful search tools; team rankings for anything from pace to point differentials adjusted for strength of schedule; and player pages with stats such as usage percentage, win shares and Box Plus/Minus. Ken Pomeroy’s site offers more detailed and adjusted team rankings and a wide array of individual player metrics. For $100 a year, Shot Analytics delivers detailed spatial analysis of shot selection, including weighted shot charts.If you’re looking for similar information to help you fill out an NCAA women’s basketball tournament bracket, you’re out of luck.Last week, leading into the MIT Sloan Sports Analytics Conference, Sue Bird wrote a piece for The Players’ Tribune about this analytic gender gap, noting, “The disparity between NBA data — even data across all male sports — and WNBA data is glaring. Data for the WNBA is relegated to basic information: points, rebounds, steals, assists, turnovers, blocks. While worthy of being noted, those are the most rudimentary numbers in our game.” There are a few slightly richer sources of data for the women’s professional game — Basketball-Reference.com will let you see the true shooting percentage and usage rate for WNBA players, for example — but Bird’s overall characterization of the data disparity is dead-on, and the effect is even stronger in college basketball. That’s true this month more than most.Until recently, the one repository for advanced statistics such as usage, true shooting percentage, pace-adjusted player statistics and adjusted team ratings for women’s college ball was WBBState.com, a vertical of data company National Statistical. But that source disappeared Feb. 29, when ServerAxis, the company that provided server space to National Statistical’s hosting company, suddenly took all its equipment offline. There are reports that ServerAxis was having financial problems, but the company has so far not responded to requests for comment. National Statistical also declined to comment on the situation on the advice of lawyers as it works to recover its data and bring the site back online.Exactly how a web hosting company pulls up anchor, ditches its Miami headquarters, and ends up 1,300 miles away in Chicago, allegedly waiting for its servers to find their way home, is almost certainly a fascinating story, but it’s secondary to the reality that an entire sport’s advanced metrics wing can be wiped off the map by a few nerds absconding with a few hard drives and turning off their phones. This is a corollary to the more global lack of statistical interrogation of women’s basketball — the data isn’t just shallow, it’s scarce, and that scarcity makes it fragile.What’s left behind is a patchwork collection of disparate scraps of data. ESPN has some statistics available for players and teams, but these cover only basic stats and are organized as leaderboards, so they can’t be searched or sorted beyond the top 50. You can find the full lists for most of those statistics, and a few others, on the NCAA’s website. It’s a thin statistical slice, and they are available for only the current season. Right now, if you wanted to find out where Breanna Stewart’s true shooting percentage ranked this season, or how many points per 100 possessions Baylor allowed, you’d need to scrape the data and calculate it yourself.A paucity of data in any sport doesn’t just trim down the “analytics” branch — it fundamentally changes the types of stories that can be told about teams and athletes. “The more data you have,” says Howard Megdal, a contributing editor for the women’s sports site Excelle Sports, “the more you have the ability to parse it, and to compare it, and to do it more easily, the more stories that are out there.”That’s no small point. In the landscape of women’s sports, college basketball in general and the NCAA Tournament in particular are enormously important. The nation’s attention has turned to college basketball, expecting rich, compelling and thorough analysis, and the women’s side, already handicapped by neglect, has lost one of its legs to a freak woodchipper accident. This leaves the writers who cover the tournament, missing servers be damned, in quite the lurch.“The NCAA has the standard points and rebounds,” Megdal says, “but I’m writing today and trying to make the point that South Carolina’s offense is actually more efficient than its defense. You know people talk about South Carolina’s defense all the time. I only knew that because of WBBState, and being able to see the tempo-free stats. So when I went to go and prove it, I can’t right now; I can’t reference those numbers. All I can do is say that they’re 17th in points per game, or whatever. And as I’m doing it, I’m well aware that I’m using a highly flawed stat that doesn’t begin to capture what I’m after.”In a way, that sums up the state of analytics in women’s basketball: Everyone knows that there are more powerful tools of observation waiting just out of reach, but there just isn’t much to do about it. Sometimes that’s because women’s leagues lack the financial might or institutional support to run in the lead pack; other times it’s because the wrong web host picked the wrong month to blow town. Our sports podcast Hot Takedown previews March Madness. More: Apple Podcasts | ESPN App | RSS | Embed Embed Code By Ian Levy read more

What The Hells Gotten Into Daniel Murphy

When theretofore ordinary second baseman Daniel Murphy turned into the reincarnation of Babe Ruth during last year’s playoffs, it was a fun story. Murphy was with the New York Mets through their lean, mediocre post-Madoff years, and he was suddenly the driving force behind their surprise World Series run. It seemed proof that in a handful of baseball games, damn near anything can happen.But for the sabermetrically minded (which presumably included the Mets’ front office), Murphy was still the decent-but-not-great player that his overall record said he was, and at age 30, he was likely on the downside of his career. So during the winter, the Mets moved on from Murphy to Neil Walker at second base — which, according to the stats, was basically the right call. Murphy signed with the Washington Nationals instead, and although projections suggested that he would have a solid season, there didn’t seem to be any way that he would build on his outlier postseason performance.Those projections have turned out to be flat-out wrong. Instead of reverting to his previous form, Murphy has looked an awful lot like the guy who went on that postseason tear: He currently ranks third in the National League in Weighted Runs Created Plus (wRC+)1A measure of a player’s runs generated per plate appearance, relative to the league, where average is 100 and higher numbers are better. and fourth in wins above replacement. (Murphy has also hit Mets pitching especially hard this year, delivering what already ranks as the most RBIs by a player against a team he played for the previous season since 1960.)For a guy who has never ranked higher than 37th in WAR, Murphy has taken a quantum leap forward. If Murphy maintains his current wRC+ for the entire season, it will be the 21st-biggest single-season improvement by a hitter over his previous career wRC+ at age 31 or older2With a minimum of 3,500 career plate appearances before the season in question and at least 350 plate appearances during the season itself. since 1901: Willie Stargell1971.398.628186.341.503134+52 PLAYERYEAROBPSLGWRC+OBPSLGWRC+WRC+ CHANGE Barry Bonds2002.582.799244.418.585164+80 Joe Morgan1976.444.576184.396.430138+46 Many of the people atop that list — including (but not limited to) Barry Bonds, Sammy Sosa, Ken Caminiti and Mark McGwire — have admitted to using performance-enhancing drugs, were named in the Mitchell Report or were otherwise implicated in baseball’s steroid scandal via leaked test results. But nothing so sinister has been mentioned to explain Murphy’s rise, and some players outside the steroid era experienced similar (presumably natural) leaps in performance.Murphy has always credited Mets hitting coach Kevin Long with making several key adjustments to his approach at the plate in an effort to help him hit for more power. Here’s Tyler Kepner of The New York Times last October, on Murphy’s swing changes:“Long believed Murphy should harness [his] power by driving more with his legs, moving closer to the plate, getting his front foot down sooner and bringing his hands lower and closer to his body.”The numbers bear this out: Murphy’s 2016 isolated power is 115 points higher than his previous career average, and he’s hitting the ball authoritatively in new areas of the strike zone. Murphy was always a solid hitter on pitches up and on the inner half of the plate, but his new approach has him driving the ball more on pitches in the middle of the plate and even ones low and away: Paul O’Neill1994.460.603171.341.443115+56 Ken Caminiti1996.408.621169.328.402102+67 Barry Bonds2004.609.812233.433.602171+62 Roy Cullenbine1946.477.537182.402.422132+50 Luis Gonzalez2001.429.688173.355.460114+59 Only includes players with a minimum of 3,500 career plate appearances before season and 350 in season.WRC+ = Weighted Runs Created PlusSource: Fangraphs Lonnie Smith1989.415.533166.362.401116+50 Of course, it’s still unlikely that Murphy has morphed into a hidden superstar after seven big-league seasons. Players in their 30s who improved on their previous career wRC+ by between 40 and 60 points in one season tended to lose 36 points of batting average, 38 points of on-base percentage and 80 points of slugging percentage the next year. But, on average, they were still better than they’d been before. Even a year after the initial breakout, they hit for a wRC+ 15 points higher than their career average had been beforehand.That means Murphy probably is a better hitter now than he was in New York. And considering the damage he’s already personally inflicted on the Mets in head-to-head competition, it also means he may well end up being the key to an NL East title for the Nationals. Not bad for a player most thought would turn back into a pumpkin after his Cinderella story last October.Check out our latest MLB predictions. Dixie Walker1944.434.529168.369.434115+53 Mike Schmidt1981.435.644198.375.526145+53 Javy Lopez2003.378.687170.332.478107+63 Jermaine Dye2006.385.622151.334.469104+47 Sammy Sosa2001.437.737186.333.523119+67 Roberto Clemente1967.400.554170.348.455118+52 Biggest hitting improvements at age 31 or older, 1901-2016 Brady Anderson1996.396.637155.349.393103+52 Barry Bonds2001.515.863235.411.567159+76 Mark McGwire1998.470.752205.382.556152+53 SEASONPREVIOUS CAREER Jimmy Dykes1929.412.539143.356.40496+47 Daniel Murphy2016.387.598157.331.424109+48 J.T. Snow2004.429.529153.353.426104+49 Rickey Henderson1990.439.577190.400.429136+54 Victor Martinez2014.409.565167.369.464120+47 Bret Boone2001.372.578149.313.41388+61 Eddie Joost1949.429.453136.332.32187+49 read more

Amazon Prime Video has turned down all of its late

first_imgAmazon Prime Video has turned down all of its latest pilot season comedies, as research from the UK points to new original content as the key driver behind SVOD take-up.Comedies Sea Oak, The Climb and Love You More will not go into development for the coming year.There is also no clear decision made on the future of comedies One Mississippi and I Love Dick.The move arrives as Amazon’s focus shifts to big dramas. In November the company paid US$250 million for the rights to J.R.R Tolkien’s The Lord of the Rings.Company chief Jeff Bezos has made it clear that content investment will go up in 2018, with an eye on globally popular shows like Game of Thrones.Amazon’s comedy choices come in the same week new data highlights the importance of premium original content to the streamers.Ofcom data shows that original content is the key driver of SVOD sign-ups in the UK. The report highlighted that 52% of UK households cite ‘original programming made by service provider’ as a reason to sign up to a streamer.Amazon also lost its head of half hour Joe Lewis in October, who resigned from the company after content chief Roy Price left amid sexual harassment claims. A replacement is yet to be named.last_img read more

Johnson Johnson to Cut 3000 jobs in Medical Devices Division

first_img –shares Johnson & Johnson to Cut 3,000 jobs in Medical Devices Division Healthcare conglomerate Johnson & Johnson said it would cut about 3,000 jobs within its medical devices division, or between 4 percent and 6 percent of the unit’s global workforce, over the next two years.The company said on Tuesday that it expected to record pre-tax restructuring charges of $2 billion to $2.4 billion in connection with these plans, of which about $600 million will be recorded in the fourth quarter of 2015.Leerink analysts said the announcement meant that an acquisition was still on the cards for J&J, given that it had about $37 billion in cash as of the end of the third quarter.”We continue to believe J&J is an active acquirer with a focus likely heavily weighted toward it’s lagging Medical Devices business…it’s a matter of when, not if, J&J does a deal”, they wrote in a note.J&J also reiterated its full-year 2015 forecast, and said the restructuring in the devices business move would not impact the $10 billion share repurchase program.The company said the restructuring would affect its orthopaedics, surgery and cardiovascular businesses within the larger medical devices unit.The consumer medical devices, vision care and diabetes care, part of the same division, would not be affected, J&J said.The restructuring is expected to result in annualized pre-tax cost savings of $800 million to $1 billion, J&J said. Most of these savings are expected by the end of 2018, including about $200 million in 2016.New Brunswick, N.J.-based J&J currently employs about 60,000 within its medical devices unit, part of a global workforce of about 127,000.The Band-Aid maker is expected to report its fourth quarter results on Jan. 26.The company’s shares rose about 1 percent to $98.25 in premarket trading.(Reporting by Natalie Grover in Bengaluru; Editing by Ted Kerr, Robin Paxton and Savio D’Souza) Layoffs Learn how to successfully navigate family business dynamics and build businesses that excel. Free Webinar | July 31: Secrets to Running a Successful Family Business Image credit: Reuters | Rick Wilking Reuters center_img 2 min read This story originally appeared on Reuters Next Article January 19, 2016 Register Now » Add to Queuelast_img read more

More Than 130000 People Have Already PreOrdered Teslas 35000Model 3

first_imgTesla 2019 Entrepreneur 360 List –shares Reuters Next Article April 1, 2016 Image credit: Reuters | Tesla Motors Handout via Reuters Tesla 3 min read More Than 130,000 People Have Already Pre-Ordered Tesla’s $35,000-Model 3 This story originally appeared on Reuters Tesla Motors gave a sneak preview Thursday of its Model 3 sedan, saying more than 130,000 people had ordered the car, even though it is more than a year away from production.Tesla Chief Executive Elon Musk unveiled a prototype of the Model 3 in Hawthorne, Calif., outside Los Angeles to hundreds of Tesla owners and the media, saying the vehicle will go into production in 2017 at a starting price of $35,000.The Model 3 is critical to the Silicon Valley automaker’s growth plans and to sustaining its lofty stock price. Tesla shares have jumped in recent days in anticipation of the Model 3 launch.The Model 3 will enter a crowded field of luxury and electric cars that includes gasoline-fueled models such as the Audi A4 and BMW 3-Series, and electric models such as the forthcoming Chevrolet Bolt EV from General Motors Co.”Do you want to see the car?” teased Musk, to screams from the audience in the hangar-sized facility inside a Tesla design center. “We don’t have it for you tonight — just kidding!”Three Model 3s were driven onstage. The compact sleek four-door car with no grille features a roof that is a panoramic pane of glass from front to back.Musk said that 115,000 pre-orders had already been taken on Thursday alone for the car. Within a half hour, that number reached 137,600 in a rolling scroll projected onto a screen.Fans had camped out overnight, queueing outside Tesla stores across California to put down deposits on the car in scenes reminiscent of the launch of Apple Inc. products.The Model 3 is crucial for Tesla to reach its goal of selling 500,000 cars per year by 2020. The success of Tesla’s Gigafactory, its battery factory near completion in Nevada, is also contingent on the Model 3.Tesla says scale from the massive facility will cut the cost of its battery pack by 30 percent to enable the lower-priced vehicle.High expectations ahead of the unveiling have restored Tesla’s shares to around the $230-mark, recovering from a year low of $141.05 in February after analysts cut price targets and revenue expectations.”It is important to the industry because it will signal whether or not Tesla Motors is a major threat to the status quo or just another wannabe car company with a fleeting chance for long-term success,” said Kelley Blue Book’s Jack Nerad.GM is on track to beat Tesla to the market with its Chevrolet Bolt electric car, which GM says will launch late this year, offering about 200 miles of electric driving range and a starting price of around $35,000.A new generation of Nissan Motor Co’s Leaf electric car is also expected to offer more driving range at a similar price.The Model 3 and others in the new generation of electric vehicles face challenges from low gasoline prices, high battery costs and uncertain investment in recharging infrastructure.Through the first two months of this year, sales of all-electric and hybrid vehicles are down nearly 9 percent to 60,384 vehicles, data from trade group the Electric Drive Transportation Association shows.That’s fewer hybrid and battery electric vehicles sold in two months than Ford sold of its F-series large pickup trucks in February alone.Several short-term concerns, such as that Model 3 production will be delayed, and the slow ramp of the Model X will continue, go hand-in-hand with skeptics’ longer-term worries that the unprofitable company will continue to bleed cash.In February, Tesla said it would start generating positive cash flow this month.(Reporting by Alexandria Sage and Joe White; Editing by Clarence Fernandez) The only list that measures privately-held company performance across multiple dimensions—not just revenue. Add to Queue Apply Now »last_img read more

China Bans Autonomous Car Testing for Now

first_img –shares Don Reisinger Self-Driving Cars This story originally appeared on PCMag Contributing Writer July 21, 2016 Image credit: PC Mag Next Article China is putting the brakes on self-driving car testing.The country’s Ministry of Industry and Information Technology drafted new regulations on self-driving car testing in the country, but until they’re approved, the government has warned companies not to try it out, according to Bloomberg, which obtained a copy of the draft.Self-driving cars are quickly becoming a hot commodity in the auto world as companies from Google to Mercedes-Benz try out the technology in the US, Europe and elsewhere. There’s no timeline on when China might approve its rules, Bloomberg says, but as auto makers eye autonomous car rollouts in the next decade, time is of the essence if China wants to keep up.Major car makers like BMW have already made plans to test self-driving cars in China. In April, Volvo said it would begin negotiations with Chinese cities that want to test Volvo’s autonomous cars using local drivers. The company wanted to use up to 100 cars to see how they work in everyday road conditions.In December, China’s Baidu also announced that its self-driving car — a modified BMW 3 Series — successfully completed testing on mixed roads under various environmental conditions. The 19-mile test drive route began at Baidu’s Beijing headquarters and covered the G7 highway, Fifth Ring Road and Olympic Park, before looping back to the starting point.In the US, semi-autonomous car technology has come under fire following the fatal accident of a Tesla Model S in Autopilot mode. Tesla has denied any wrongdoing, reiterating that Autopilot is semi- and not fully autonomous and promising an upgrade soon, but regulators are investigating. 2 min read China Bans Autonomous Car Testing (for Now) The only list that measures privately-held company performance across multiple dimensions—not just revenue. 2019 Entrepreneur 360 List Add to Queue Apply Now »last_img read more

Acquia Unveils New Compliance Security Capabilities for Acquia Cloud

first_img“These new capabilities for Acquia Cloud empower our customers with insightful governance by providing foundational security principles directly to our customers,” said Joseph Janik, chief information security officer at Acquia. “Built on AWS’ platform, these innovations provide deeper insights into hosted applications along with a comprehensive set of security capabilities.”“In today’s world, cybersecurity is more important than ever. That’s why Mobomo is working closely with leading-edge government agencies to tackle their cloud-first initiatives through FedRAMP cloud platform-as-a-service offerings,” said Ken Fang, president of Mobomo. “Acquia’s new security capabilities ensure that our customers stay up-to-date on the latest security requirements through better integration into hybrid cloud environments and increased flexibility in both configuration and control. In addition, continual updates to the security features of the platform enables Mobomo to provide seamless integration and up-to-date security solutions to our customers in a cost-effective and efficient manner. These capabilities give Mobomo and their customers comfort knowing their information is safe, while allowing us to focus on what really matters — delivering more features and functionality to our end users.”Marketing Technology News: Fishbowl, Inc. Names New Chief Revenue OfficerAcquia Cloud enhancements include the following:SSO: An upgraded SSO service seamlessly unifies management of internal and external user authentication, protecting sensitive information and offering improved governance across IT managed systems.Log Forwarding and SIEM integration: Customers can easily configure Acquia Cloud to share logs securely with their Security Information and Event Management (SIEM) systems, thereby providing more visibility to improve incident detection and response. Acquia Cloud supports forwarding logs to popular SIEMs including Splunk and SumoLogic.Access and Governance: Acquia Cloud Shield, a private, isolated cloud for sites that require heightened levels of secure access, now offers optional VPC peering so companies may connect their AWS-hosted VPCs. Additionally, customers may use a self-service UI to manage access for greater administrative flexibility.FIPS 140-2: Acquia offers support for the Federal Information Processing Standard (FIPS) 140-2, a U.S. government standard that defines cryptographic module security requirements and is critical for federal customers.Marketing Technology News: Where’s Our Data? IDC Executive Brief – Data Control is Crucial for Success in Digital Transformation AcquiaAcquia CloudDigital Experience PlatformsFederal Risk AuthorizationMarketing TechnologyNewsSecurity Information Previous ArticleQuality Data Equals Truth Sets, and Nothing LessNext Article60% of Users Will Disable Ad Blockers for Certain Domains, Indicating an Opportunity for Advertisers Provides Broadest Set of Compliance & Security Services Available for Enterprise Drupal Deployments Acquia Unveils New Compliance, Security Capabilities for Acquia Cloud PRNewswireApril 25, 2019, 7:37 pmApril 25, 2019 Acquia announced new capabilities for Acquia Cloud, extending the company’s strengths in security innovation and compliance for digital experience platforms. Additions include new tools to manage risk and updated compliance for a pair of key US federal standards, providing the security and compliance that companies require. These updates expand upon the broadest set of compliance and security services available anywhere on a single cloud platform for Drupal deployments.Acquia Cloud provides a secure, resilient and broadly supported cloud platform. The cloud-native platform enables customers to build and manage Drupal-based digital experiences, freeing staff to innovate on every channel, engage customers, and grow their brands.As global brands expand the breadth of digital offerings, they need to ensure that customer data is secure at every touchpoint. These new capabilities give enterprises the ability to provide protection without taxing the resources of security and operations teams. New security capabilities include upgraded single sign-on (SSO) integrations, greater support for SIEM log forwarding, and upgraded controls for access and governance. Acquia customers can also increase their levels of assurance with Acquia’s adherence to new facets of the Federal Risk Authorization and Management Program (FedRAMP) and Federal Education Records Privacy Act (FERPA) compliance standards.Marketing Technology News: BSI Reports Top Supply Chain Themes for 2019last_img read more

Osteoporosis is not only a womens disease

Reviewed by Kate Anderton, B.Sc. (Editor)Dec 18 2018UMass Lowell wins $2.6 million grant to study bone health in menOsteoporosis, a bone disease that can result in painful fractures – typically in the back, hip or wrist – is often thought of as a woman’s disease. But men get it too, just usually later in life than women.Segment the population even more and researchers find that Puerto Rican men who live on the U.S. mainland are at much greater risk of thinning bones than previously thought. Researchers at UMass Lowell will assess bone strength and nutrition among men and women in this population in a study that could lead to improvements in treatments for all people who suffer from osteoporosis.The National Institutes of Health has awarded $2.6 million to UMass Lowell researchers to evaluate bone health risks among this population. The research team is led by UMass Lowell Prof. Katherine Tucker and includes assistant professors Kelsey Mangano and Sabrina Noel of the Biomedical and Nutritional Sciences Department.Related StoriesTop four things seniors need to know to have a safe and healthy summerUMN research evaluates impact of multimorbidity on hip fracture probability in older womenPenn study reveals link between mitochondrial damage and osteoporosisThis study is among the first of its kind to examine whether differences in bone strength between adults with and without Type 2 diabetes are due in part to compounds called advanced glycation end products (AGEs).Found in many foods and formed when meats are grilled, roasted, seared, fried or baked, AGEs contribute to increased oxidant stress and inflammation, which are linked to the recent epidemics of diabetes and cardiovascular disease.”Studying the relation of AGEs to bone health is novel among humans,” said Tucker, who also leads UMass Lowell’s Center for Population Health. “We expect that the research results will provide insight for developing interventions to prevent bone loss and fracture risk in adults.”The UMass Lowell team will study about 800 people living in the Boston area who are also participants in the Boston Puerto Rican Health Study Projects, which is a series of in-depth studies conducted over the past 12 years that has allowed researchers to follow the nutrition and health risk factors of 1,500 members of this population.Participants in the UMass Lowell study will complete a questionnaire, provide blood samples and get bone scans. In addition to the bone mineral density test that measures bone loss, the research team will use a new approach that assesses bone strength.”We know now that the bone density scans that we use today do not capture the full extent of fracture risk,” said Tucker. “In our study, we’ll be using microindentation, a new test that measures bone material strength. Using this new method in combination with the bone mineral density test will give us a better picture of bone health as it relates to nutrition and other health factors.”Early this year, Tucker received a $3.9 million grant from the NIH to study the effect of highly processed foods on dementia in this same population. Source:https://www.uml.edu/ read more

BGU develops new AI platform for monitoring and predicting ALS progression

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Feb 20 2019Technology will also improve drug development and clinical trials for neurodegenerative diseasesBen-Gurion University of the Negev (BGU) has developed a new artificial intelligence (AI) platform for monitoring and predicting progression of neurodegenerative diseases to help identify markers for personalized patient care and improve drug development.The platform, developed by Prof. Boaz Lerner of the BGU Department of Industrial Engineering and Management will initially be used for amyotrophic lateral sclerosis (ALS) and ultimately for Alzheimer’s, Parkinson’s and other neurodegenerative diseases.”One of the big challenges of designing and managing clinical trials for ALS is that it is a rare disease, and clinical variability makes it hard to identify markers for severity,” says Prof. Lerner. “As a result, after decades of research, there is still no real cure for ALS and several other challenging neurodegenerative diseases, including Alzheimer’s.”Our new technology will more accurately predict disease progression, a crucial ingredient for clinical trials, and better identify the interrelationships between demographics and other measurable factors identified through physical examinations and patient functionality.”ALS, also known as Lou Gehrig’s disease, is a fatal neurodegenerative disease that causes death of motor neurons which control voluntary muscles. This muscle atrophy leads to progressive weakness and paralysis, difficulty speaking, swallowing and breathing. The average survival time for people who are typically diagnosed between ages 40 to 60 is two to five years from onset of symptoms.Related StoriesUsing artificial intelligence to personalize the dose of radiation therapy for cancer patientsNovel imaging molecule reveals brain changes linked to progressive MSEndogenous retrovirus type W found to be a major contributor to nerve damage in MSALS population heterogeneity complicates research and drug development because of symptom variability at onset, disease progression rates and patterns, and survival statistics. This variability makes it difficult to predict disease progression rate and pattern for individuals.Having a reliable personalized prediction platform could improve patient care and quality of life for many patients and their caregivers. The new AI platform could also improve clinical trial design by identifying markers for various patient sub-populations’ treatment.The BGU platform integrates demographic and clinical data with machine learning and data mining algorithms to produce models that can predict the rate and pattern of ALS progression, identify specific lab tests or vital signs, and stratify similar sub-groups from the diverse ALS population. The algorithms, and their ability to predict disease progression, will improve as clinical data is added for each patient.”Now that the algorithms required to produce effective models have been established and evaluated, the funding we received from the Israel Innovation Authority will enable researchers to create a system that patients, physicians, caregivers, pharmaceutical companies, HMOs, and insurers can use on desktop and mobile applications to monitor and predict ALS progression,” says Itzik Mashiach at BGN Technologies, BGU’s technology-transfer company.”We are now seeking an industry partner to further develop and commercialize this innovative patent-pending technology.”​ Source:https://aabgu.org/nlast_img read more

UMN study shows impact of opioids on pain and survival in sickle

first_img Source:https://www.med.umn.edu/news-events/university-minnesota-researchers-study-effect-chronic-opioid-therapy-pain-and-survival-sickle-cell-disease Reviewed by James Ives, M.Psych. (Editor)Apr 3 2019New UMN research recently published Blood Advances, Kalpna Gupta, PhD, Professor of Medicine, University of Minnesota Medical School, demonstrates the impact of opioids on the survival of humanized mouse models with sickle cell disease, compared to normal mice.Sickle Cell Disease (SCD) affects millions of people throughout the world. The genetic disease worsens over time and can cause lifelong pain. Given the often severe nature of the pain associated with SCD opioid use is a rule not an exception for treatment. The mice in this study showed characteristics of pain observed in patients with Sickle Cell Disease (SCD).Related StoriesAlternate cell growth pathway could open door to new treatments for metastatic cancersNanoparticles used to deliver CRISPR gene editing tools into the cellSleep quality and fatigue among women with premature ovarian insufficiency”We wanted to know if opioids reduce survival,” said Gupta. “There was a distinct difference in survival with morphine treatment between control mice expressing normal human hemoglobin and sickle mice expressing human sickle hemoglobin.” Gupta and her colleagues found that chronic morphine treatment decreased survival in control mice, but not in sickle mice.Adverse effects of opioids from clinical studies in cancer show the association of opioid requirement with reduced survival. Patients with SCD have reduced survival. Since many use opioids long-term, it is critical to know if opioids reduce survival in SCD and if they are really required. Researchers also looked into whether opioids caused hyperalgesia, a condition where a person develops an increased sensitivity to pain. They found that chronic morphine treatment leads to hyperalgesia in sickle mice, but does not lead to analgesic tolerance.”Our findings show that opioids cause hyperalgesia, which means they do cause pain, and that is why there is an increased requirement of morphine as the time goes by, it may not due to the reward function.” This study provides evidence for the first time that opioid requirement in SCD may be genuine and is not causing an adverse effect on survival and that even after long-term use opioids continue to remain effective in treating pain.According to Gupta, it would be critical to perform observational analysis on SCD patients receiving opioids to validate these findings, so that their pain can be managed effectively without opioid phobia amongst the providers. Until alternatives to opioids are found, pain needs to be treated with opioids. However, this study in humanized sickle mice also highlights the unmet need to develop effective analgesics to treat pain in SCD and in many other conditions.last_img read more

Peanut allergy tolerance treatment may increase the risk of anaphylaxis

first_imgBy Sally Robertson, B.Sc.Apr 26 2019Reviewed by Kate Anderton, B.Sc. (Editor)Treating children who have a peanut allergy by gradually exposing them to increasing levels of peanut extract may actually increase their risk of allergic attacks, instead of inducing tolerance, warn researchers from McMaster University.The team found that efforts to desensitize children with peanut oral immunotherapy resulted in three times as many allergic reactions in the “real- world,” compared with peanut avoidance.Children who tried the desensitization method also had more severe reactions, including potentially fatal anaphylactic reactions that required administration of life-saving adrenaline.More than six million people are affected by food allergies across Europe and North America, most of whom are children. While children often grow out of the more common egg or milk allergies by the age of ten, a peanut allergy can persist into adulthood and be a lifelong problem.What is oral immunotherapy?Previous research has suggested that oral immunotherapy, where allergic children are gradually exposed to increasing levels of peanut extract, can desensitize a child to peanuts, reducing their risk of anaphylaxis.Researchers say that despite an increased risk of reactions during the initial exposure phase, the ultimate benefits could last a lifetime. Findings from a study last year provided the most convincing evidence to date that the exposure method can stop peanut ingestion triggering a fatal reaction.However, studies assessing the effectiveness of oral immunotherapy measure the treatment’s success by whether a person can pass a supervised food challenge. Dr. Derek Chu (McMaster University) and colleagues point out that this cannot serve as a predictive measure of a person’s future risk in the real world.The treatment may not work in the ‘real-world’Through the analysis of findings from 12 trials, Chu and team questioned whether the results of desensitization studies can be replicated in the real world and have raised concerns about the safety of such approaches. The research was published in The Lancet. Oral immunotherapy is an emerging experimental treatment for peanut allergy, but its benefits and harms are unclear. We systematically reviewed the efficacy and safety of oral immunotherapy versus allergen avoidance or placebo (no oral immunotherapy) for peanut allergy.”Dr. Derek Chu Safer peanut allergy treatment approaches and rigorous randomised controlled trials that evaluate patient-important outcomes are needed.”center_img The team pooled data available for more than 1,000 children (aged an average of nine years) who had participated in oral immunotherapy trials and whose progress had been followed for one year.“Our study synthesizes all randomized clinical trials comparing peanut oral immunotherapy to no immunotherapy in order to generate the highest quality evidence to inform decision-making,” says Chu.The analysis found that 22.2% of children who underwent oral immunotherapy therapy experienced anaphylactic reactions, compared with 7% who avoided exposure to peanuts.Serious allergic reactions that led to vomiting, hives, abdominal pain, wheezing and asthma were all increased, including potentially fatal attacks where life-saving adrenaline needed to be given.The findings favor avoidance of overall current forms of oral immunotherapy and suggest that children who avoid peanuts altogether have fewer attacks overall.‘More allergic and adverse reactions’Chu adds that although the exposure method can achieve the aim of desensitization, “this outcome does not translate into achieving the clinical and patient-desired aim of less allergic reactions and anaphylaxis over time.”Instead, the outcome is the opposite, he says, with “more allergic and adverse reactions with oral immunotherapy compared with avoidance or placebo.”Chu emphasizes that the study does not denounce current research into oral immunotherapy, but that the method should be more carefully considered, with improvements in safety made and measures of success being aligned with patients’ wishes.last_img read more

Amazon primed to hire 2000 new employees in France

Explore further US online shopping giant Amazon said Thursday it plans to create 2,000 permanent full-time jobs in France this year as consumers are making more and more of their purchases via the internet. © 2018 AFP “The jobs are at all levels of skills” even if “the overwhelming majority of the positions are for fulfilling orders,” Amazon’s director in France Frederic Duval told AFP.The new jobs will be across Amazon’s distribution centres in France, as well as its offices in the Paris region, and take overall staff to 7,500.Amazon said it has invested more than two billion euros ($2.5 billion) in France since 2010 and created more than 1,500 jobs in France last year.However Amazon, along with other US tech companies, has also been at loggerheads with French authorities over taxes as they structure sales to pass through other European countries where tax rates are lower.Amazon announced earlier this month it had reached an agreement with French tax authorities under which it will now register French sales in France. The 2,000 new jobs will take Amazon’s overall workforce in France to 7,500 Amazon hammers out tax deal with France Citation: Amazon primed to hire 2,000 new employees in France (2018, February 15) retrieved 18 July 2019 from https://phys.org/news/2018-02-amazon-primed-hire-employees-france.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Germany wants automakers to pay up as more diesel bans loom

first_imgIn this Oct. 9, 2018 file photo exhaust pipes of a car are pictured in Berlin, Germany. The German government is putting pressure on the country’s automakers to fix diesel cars with excessive emissions, in a bid to placate drivers angered by the prospect of driving bans in major cities. (AP Photo/Michael Sohn, file) The German government is putting pressure on the country’s automakers to fix their diesel cars that have excessive emissions, in a bid to placate drivers angered by the prospect of diesel driving bans in major cities. The newly announced measures by Merkel’s Cabinet will apply to 15 German cities that significantly exceed the European Union’s limit of 40 micrograms of NOx per cubic meter. Another 50 cities in the country are just above the EU threshold.Merkel’s party and her coalition allies, the Social Democrats, are projected to face steep losses in the Hesse state election on Sunday, while the environmentalist Green party has seen a surge in opinion polls in recent weeks.Ferdinand Dudenhoeffer, one of Germany’s best-known auto industry analysts, called the government’s new measures “a transparent election campaign maneuver for the Hesse vote.”He told the daily Rheinische Post that Merkel had known about the problem of excessively high NOx emissions since 2010, but refrained from doing anything about it.The government announced its measures on the same day a court in Stuttgart, Germany, ruled Volkswagen’s parent company, Porsche SE, must pay investors 47 million euros for not making timely disclosure of its 2015 diesel emissions scandal, in which Volkswagen rigged cars to cheat on diesel emissions tests.Porsche SE said it would appeal and that the claims were “without merit.”The Volkswagen scandal led to closer scrutiny of diesels in general, which were found to often emit more pollutants in regular driving than in testing because automakers exploited loopholes allowing them to turn off emissions controls to avoid engine damage in certain circumstances. Testing procedures were tightened as of Sept. 1 to more closely reflect real-life emissions. German Chancellor Angela Merkel sits between Vice-chancellor and Finance Minister Olaf Scholz, left, Head of Chancellery and Minister for Special Tasks Helge Braun, right, as she leads the weekly cabinet meeting of the German government at the chancellery in Berlin, Wednesday, Oct. 24, 2018. (AP Photo/Markus Schreiber) © 2018 The Associated Press. All rights reserved. Porsche first German carmaker to abandon diesel enginescenter_img Citation: Germany wants automakers to pay up as more diesel bans loom (2018, October 24) retrieved 17 July 2019 from https://phys.org/news/2018-10-germany-automakers-diesel-loom.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Chancellor Angela Merkel’s Cabinet agreed upon a series of measures Wednesday that includes upgrades for older vehicles affected by the diesel scandal , preventing them from being subjected to diesel driving bans in cities such as Hamburg, Berlin, Stuttgart and Frankfurt.”It’s not acceptable that that the auto industry is paying a lot of money in America , but makes a huge fuss over a few hundred euros (dollars) here,” Merkel said at an election rally in the state of Hesse late Tuesday, calling on car makers to stop penny-pinching when it comes to fixing the cars they sold to consumers with misleading emissions claims.The German transport ministry has said it believes about 2.2 million vehicles need upgrades.Merkel’s unusually harsh words toward Germany’s powerful auto industry came the day before a court in nearby Mainz considered whether a ban on diesel-powered cars is permissible to prevent air pollution in the city.Diesel vehicles are a significant source of nitrogen oxides, or NOx, which can be harmful to human health. The Mainz administrative court decided Wednesday that the city would have to prepare to implement a ban on older diesel vehicles by Sept. 1, 2019, if NOx levels cannot be reduced by then.last_img read more

As campaign concludes in AP Jagan Reddys remarks on Amaravati leave voters

first_imgpoll campaign SHARE SHARE EMAIL Andhra Pradesh April 09, 2019 As the campaigning concluded in Andhra Pradesh on Tuesday, for the poll to be held on Thursday, a doubt is lingering in the minds of voters, especially in Krishna and Guntur districts. It relates to Amaravati, the new capital.In interviews given to English and Telugu channels, the YSR Congress leader, YS Jagan Mohan Reddy, described Amaravati as a huge scam perpetrated by Chief Minister.‘Huge scam’On Tuesday, the last day when Jagan campaigned in Mangalagiri constituency in Guntur district in the new capital region, he explained to the voters the huge scam allegedly perpetrated by N Lokesh, Chief Minister Chandrababu Naidu’s son and State IT Minister, is contesting from Mangalagiri as the TDP candidate.Jagan said, “We also welcomed the decision initially, though we did not approve the method of arriving at the decision, and we had our reservations. But then the Chief Minister cleverly encouraged speculation on where exactly the capital will come up, knowing well the exact location and keeping it to himself and his friends and cronies, and giving an impression to the people that it might come up elsewhere.“His friends, cronies and benamis bought huge parcels of lands near the present location, Amaravati, at throwaway prices. Then, he announced the location. Others who bought land at other locations lost heavily… And the scam did not stop there.”He alleged that the Chief Minister acquired 33,000 acres from farmers through the land-pooling method, ensuring that the land-parcels of his cronies, friends and benamis were excluded from the core capital area.“The prices of these lands abutting the capital area shot up. The farmers who have lost the lands are very unhappy. Then, the CM started allotting the lands in the core capital area to companies in the name of capital development. It is a huge scam, the biggest in the history of the State,” Jagan Reddy alleged.On Tuesday, while campaigning in Guntur district, Chandrababu Naidu said, “If Jagan comes to power, all development in the State will come to a halt. In particular, Amaravati and the Polavaram project will suffer. He is not interested in Amaravati.”This issue will have a bearing on the minds of the voters in two very important coastal districts — Krishna and Guntur — though the rest of the State will also be affected to some extent.If he comes to power, what Jagan intends to do with Amaravati, which he describes as a huge scam, is anybody’s guess. Published on SHARE YS Jagan Mohan Reddy   –  CH VIJAYA BHASKAR political campaigns state politics Chandrababu Naidu COMMENT COMMENTSlast_img read more