Beneficial black flies?

first_imgBlack flies vector river blindness while drinking their blood meal. A threat in sub-Saharan Africa, river blindness is a parasitic disease caused by a nematode infection. It’s not caused by nematodes themselves. A symbiont that the nematode releases when it dies triggers an inflammatory response that causes changes in the skin and chronic inflammation. Eventually, the symbionts migrate through the eyes, causing the cornea and lens to cloud and leave infected people blind. This discovery made the protein attractive as a potential drug target, possibly one to treat patients recovering from heart attacks. “In order to feed on blood, these insects have to contend with our natural defense agents against blood loss—like clotting,” he said. “Many insects use salivary injections packed with proteins to inhibit the enzymes in our bodies from reacting the way they normally would to injury.” In order for insects to earn a blood meal, they have to override the human body’s battery of defenses. Most of these insects have anticoagulants to fight off clotting, inhibitors to stop clumping of platelets and vasodilators to speed up blood flow at the bite site. “As it turns out, there are also a lot of things in saliva that modulate the immune response like inflammatory responses and downstream immune responses,” he said. “We are not rearing black fly vectors; they are not being infected with the parasite that causes river blindness; and there is no risk to the public,” he said. “These salivary factors change the environment for the parasite so it’s conceivable that knowing about this protein would allow us to target it in some way, maybe by vaccinating against it, and that would likely make it less favorable for the transmission of river blindness,” he said. What they are doing is learning more about how the disease is transmitted and how to possibly stop it. Black flies drink blood and spread disease such as river blindness—creating misery with their presence. A University of Georgia study, however, proves that the pesky insects can be useful. “Inflammation is a major source of tissue damage associated with vascular injuries,” he said. “The idea of a single factor that could both inhibit clotting and inhibit damaging inflammation responses at the same time is pretty novel and interesting.” These enzymes are able to kill bacteria, and they help drive the inflammatory response. Don Champagne, an entomology professor with the UGA College of Agricultural and Environmental Sciences, discovered a way to use the black fly’s blood-sucking tactics for medical advancement. The results of his research were published in the journal PLoS One. “We were able to show that the salivary protein targets Xa and is a good inhibitor of clotting,” he said about his recent research. “But, it is an even better inhibitor of some enzymes involved in very early immune response—elastase and cathepsin G.” “We were expecting these to be anticoagulants, that wasn’t a surprise,” he said. “But, we were surprised to learn that the protein affected all of these other responses.” Studying black flies is easier at UGA than anywhere else, because UGA has the only black fly colony in the world. The flies in the lab aren’t the same ones who transmit the debilitating river blindness disease, but the unique resource enables important research about the transmission of river blindness. “A lot of blood feeders also vector diseases,” Champagne said. “When they are playing all of these tricks on the host in order for them to get a good blood meal, they change the conditions at the point where these pathogens go into the skin. Those changes often favor the pathogen. In an environment where normal wounding responses and defenses are inhibited, the pathogen can go in and say ‘oh, look at that—the door is wide open.” A few years ago, Champagne worked on a study transcribing the messenger RNA that codes for proteins found in the salivary secretions of the black fly. He found two proteins that looked like they could hinder clotting. Champagne determined that one of these inhibits the clotting cascade by blocking factor Xa. Clotting factors exist in the blood in an inactive state, waiting to be called into action. Because these factors work like dominos, if factor X fails to be turned on (converted to Xa) the rest of the responses stay inactivate.last_img read more

This is real estate’s billion dollar man, having sold more than $1.2 billion worth of property

first_imgThousands of real estate agents attended AREC 2017 on the Gold Coast.More from newsMould, age, not enough to stop 17 bidders fighting for this home4 hours agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor4 hours agoWolff shared his knowledge on achieving “superstar success” to 4500 industry professionals at the Australian Real Estate Conference 2017 on the Gold Coast. He also revealed he hasn’t always been a superstar. The real estate guru started in the industry at the age of 22, went bankrupt six years later, his wife left him and he started smoking five packs of cigarettes a day. “I should be dead,” he said. He turned his life around with the power of self belief and having life goals – a long list of which he writes down every year. Those goals even include pictures of the possessions he intends to accumulate – a luxury boat, a fancy watch, a trip aboard The Orient Express.“You’ve got to have goals because if you don’t know what it is, how are you going to know what you want?” he said. “Do what you said you were going to do … that’s what makes you money!”Wolfe stressed the importance of “dollar productive behaviour” – looking and acting the part, giving out five business cards a day, returning phone calls and doing an open house every day for one year. But it’s a simple piece of advice that he’s predicated his entire career on. “Never forget the basics,” he said.That includes picking up the phone and talking to people, staying focused, eliminating negativity, staying hungry and, most importantly, “never give up!”Bob Wolff was the very first speaker at AREC when it started 20 years ago, and by the end of his presentation this year, he was declared the conference’s best speaker ever. Bob Wolff at AREC with John McGrath of McGrath Real Estate. Picture: Matthew Foster.THEY don’t call him the “Billion dollar man” for nothing. Now in his 44th year of selling houses ‘one at a time’, one of America’s top real estate agents, Bob Wolff, has amassed over $1.2 billion in sales. And just a few minutes in to his energetic and inspirational presentation at AREC 2017, it was clear to see why. The 64-year-old confessed he lives only a block from the beach yet has never been. This is a man who had a pool for 10 years but had never swum in it, so he took it out and replaced it with a spa, which he used for the first time the other day only because he accidentally fell in it!His idea of a merry Christmas is selling a house on Christmas Day.“List, sell, delegate and negotiate,” he said. “I do nothing else.”But he absolutely loves it. “Love what you do!”last_img read more

New-ball bowlers Connell and Selman named in Windies squad to face Sri Lankans

first_imgST JOHN’S, Antigua, (CMC) – New-ball bowlers Shamilia Connell and Shakera Selman have been passed fit and included in a 13-member West Indies Women’s squad to face Sri Lanka in the three-match One-Day International series which bowls off next week.The Barbadian duo had been named in the 19-member training squad last month subject to clearance from the Cricket West Indies medical panel, after both suffered tournament-ending injuries during last July’s Women’s World Cup in England.Connell was limited to just two matches, picking up a hip injury in her second outing against India at Taunton while Selman suffered a blow to the head in the opening match against Australia and never played again.The pair will form part of a strong unit, all of whom were part of the disappointing World Cup campaign.Chief selector Courtney Browne said while it had been intentional to keep the core of the squad together, selection had also been based on the attitude of players during the recent camp in Trinidad.“The final squad as we mentioned previously, would have been based on a strong work ethic during the training camp that was held over the last couple of weeks,” Browne said.“Focus was also placed on selecting a balanced squad, noting that some of our key players are all-rounders. We have maintained a core group of players that have performed before for the team, along with a few young players and we must now allow the coaching staff to drive performance.”No place has been found again for experienced batsman Britney Cooper who was the only member of training group not to travel to the World Cup.Shanel Daley has also missed out after managing just 60 runs in five innings during the World Cup while Qiana Joseph, Felicia Walters and Subrina Munroe have all been overlooked.The squad will be led as usual by Stafanie Taylor with seasoned off-spinner Anisa Mohammed as her deputy.Experienced campaigners Merissa Aguilleira and Deandra Dottin, both with over 100 ODIs, are also in the squad.The series will be the first for the side since the wretched World Cup campaign where they managed just two wins in seven matches, and Browne said an improved performance was expected.“We expect to see more of an overall team approach to the different facets of the game and to see more players taking responsibility for team performance, thus realising more of a team effort in winning matches,” he said.The three ODIs to be played on October 11, 13 and 15 at the Brian Lara Stadium in Trinidad will form part of the new round of matches in the ICC Women’s Championship.SQUAD – Stafanie Taylor (captain), Anisa Mohammed (vice-captain), Merissa Aguilleira, Reniece Boyce, Shamilia Connell, Deandra Dottin, Afy Fletcher, Kyshona Knight, Kycia Knight, Hayley Matthews, Chedean Nation, Akeira Peters, Shakera Selman.last_img read more

Red Bank Sidewalk Sales This Weekend

first_imgVisitors to Red Bank also will enjoy free StreetLife performances from noon to 3 p. m. and then 6 to 9 p.m. Saturday and from noon to 3 p.m. on Sunday. Family entertainers will include musicians, magicians and face painters. Red Bicycle Shop owner Jonathan Erdelyi, left, shows Fair Haven Mayor Ben Lucarelli some sneakers during the annual Red Bank Sidewalk Sale.RED BANK – The 59th Annual Red Bank Sidewalk Sale has begun.The borough’s annual sidewalk sale will be held from 9 a.m. to 8 p.m. Friday and Saturday and from 10 a.m. to 5 p.m. Sunday.Clearance items and bargains will be available at Red Bank stores with many offering great times from tables set up in front the shops, businesses and antiques stores on Broad, White, Monmouth, Front and Wharf streets and Bridge and Maple avenues.last_img read more

Dam Inn, Our Glass secure place at top of WKMFFL with weekend wins

first_imgDam Inn Mates survived a late scare from the Thundercats to get past Trail 25-17 in West Kootenay Men’s Flag Football League action Sunday at Mount Sentinel Field.The victory keeps the Mates atop the WKMFFL standings with an undefeated mark of 4-0.Nelson Our Glass Ogs kept up the pressure on the Mates by blasting defending league champion Castlegar Vikings.Our Glass is second in league standings with the same amount of points — eight — but has played one more game with a record of 4-1.The league resumes Sunday with a pair of games at Mount Sentinel.At 11 a.m. Rossland Flying Steamshovel Brewers tackle Trail Thundercats while the Mates face Castlegar Vikings at 1 p.m. The game between Castlegar and the Mates is a rematch of last year’s league final won by the [email protected]last_img read more

Nitros even Kootenay Conference series with 3-2 win over Nitehawks

first_imgSecond period goals by Nolan Kurylo and Nic Herringer proved to be the difference as Kimberley erased a 1-0 Beaver Valley first-period lead.Franco Colapaolo scored an insurance marker into the empty net in the third period to secure the road win for Kimberley.Mitch Foyle, with time running out in the third, and Bradley Ross, scored for the Hawks.Cody Campbell registered the win in goal for the Dynamiters as Beaver Valley out shot the visitors 28-21.Beaver Valley’s Tallon Kramer lost in goal for the first time in the 2017 playoffs.If necessary, Game five is scheduled for Friday in Beaver Valley.In the Okanagan/Shuswap Conference, Osoyoos Coyotes hold a 1-0 series advantage with Game two Sunday in the South Okanagan City. After coasting through the Murdoch Division, winning eight straight, and the first game of the Kootenay Conference series, the Beaver Valley Nitehawks now face some adversity against the Kimberley Dynamiters.The Nitros scored a much-needed road victory, edging the Hawks 3-2 in Kootenay International Junior Hockey League Conference Playoff action Saturday in Fruitvale.The win evens the best-of-seven Kootenay Conference Final at 1-1 with Games three and four, Tuesday and Wednesday, in the Bavarian City.last_img read more

Giants mailbag: What will the franchise do to win back fans after hiring Gabe Kapler?

first_imgSAN FRANCISCO — In the last eight days, the Giants have hired a new general manager and field manager, lost closer Will Smith to the Braves and had ace Madison Bumgarner reject a qualifying offer to return to San Francisco.In other words, it’s been a tumultuous week for a franchise that has had a tumultuous 12-plus months.The Giants have dealt with several high-profile off-the-field incidents in the last year and their decision to hire Gabe Kapler as field manager angered many fans and forced …last_img

Geocaching Caption Contest 12 – Win a Barely Coveted Prize

first_img SharePrint RelatedGeocaching Caption Contest 13 – Win a Barely Coveted PrizeSeptember 26, 2010In “Lackeys”Geocaching Caption Contest 11 – Win a Barely Coveted PrizeAugust 20, 2010In “Community”Geocaching Caption Contest 10 – Win a Barely Coveted PrizeAugust 4, 2010In “Community” Winning Caption: “I pledge allegiance to this cache and to the other caches hidden ’round hereand to this gray rock on which I stand,one drunk gnome, holding grog, intoxicated,with stealthiness from muggles and all. ” -AnewlesmizThis is the twelfth installment of our Geocaching Caption Contest.  You might have seen this picture posted to Geocaching.com’s Facebook page.  It was too good not to share here on the Latitude 47 blog.What caption would you write? “Mmmm… that geocache looks tasty.” You can do better.The winner receives what’s a fairly coveted prize, celebrating the launch of Signal the Frog’s Facebook page.  The winning caption receives the Signal antenna ball.Click here to see the winning captionBarely coveted prizeGood luck!  Please include your geocaching username in all entries.The winner of the twelfth Geocaching Caption Contest will be chosen by an ad hoc committee of Lackeys.15 Lackeys voted to award the winner of the eleventh Geocaching Caption Contest a barely coveted prize.Click on the picture to the right to see who won a barely coveted prize.Explore the wit and wisdom of geocachers by checking out all the Geocaching Caption Contests.Share with your Friends:Morelast_img read more

Tacit Interactions and Knowledge Workers

first_imgJames Manyika of McKinsey Silicon Valley last week had an article called “The coming imperative for the world’s knowledge economy” in the Comment section of the Financial Times.  Manyika and others at McKinsey have argued that the term Knowledge worker and its definition as people “who think for a living” covers too big of a group of people. Manyika observed that certain types of knowledge workers have more impact on the success or failure of a company.  He found that these key workers typcially are involved in high levels of what he calls of “tacit interactions“.  Tacit interactions usually involve making complex judgments, problem-solving and exchanging information.  Industries where tacit interactions frequently occur are publishing, healthcare and  software.  And it’s in these industries where the gap between the best and worst performers is the greatest.Manyika argues that the past decade has seen IT excel at automating transactions, and that the next decade of IT will shift emphasis from efficiency to effectiveness.  He sees part of this happening with IT collaboration tools that can act as enablers of more efficient tacit interactions.This week the annual AIIM show was held in Philadelphia.  Manyika’s ideas are playing out there.  AIIM has evolved and the emphasis has changed considerably since the early days when the focus was on strictly Imaging and Document Management.  There is keen interest in companies like Formtek that are providing Collaboration and Business Process Management solutions. Current hot topics at AIIM like Distributed Capture aren’t emphasizing the volume and processing speed; they focus on improving the task of getting information into the system as fast as possible, so that the most current data can be made available for making the best decisions.last_img read more

ADLINK: insights on how to transform current factories into factories of the future

first_imgADLINK Technology enables computing at the edge of the network, whether that network be the public Internet or an enterprise information technology/operational technology network. With the main goal of driving data-to-decisions, ADLINK provides solutions to connect the unconnected and simplify the design, development and deployment of Industrial Internet of Things applications. Through the integration of computing power, rugged design, high availability and industrial I/O, ADLINK has made a name for itself providing reliable products of superior quality for cost-effective solutions.The Factories of the Future can’t be built overnight. Their current infrastructure needs to be upgraded by using advanced technologies such as Artificial Intelligence (A.I.), Robot Operating System (ROS), Data Distribution Services (DDS), Time Sensitive Networking (TSN) and more. At Embedded World, you will gain the insights and blueprint of how ADLINK can help you to transform the current factories to factories of the future.Share this:TwitterFacebookLinkedInMoreRedditTumblrPinterestWhatsAppSkypePocketTelegram Tags: Boards & Modules Continue Reading Previous LieberLieber: PiCar as model for Industry 4.0Next The Benefits of C and C++ Compiler Qualificationlast_img read more